Hippocampal Activity Measurement
The hippocampus is a brain structure that
plays a vital role in the encoding of new
memories.  In Alzheimer's Disease, the
hippocampus is one of the earliest regions
to deteriorate.  Glucose metabolism in the
hippocampus begins to decrease years
before symptoms appear (Mosconi et al,
2008, 2009), and thus is an important
diagnostic marker.  However, hippocampal
glucose metabolism is very difficult to
measure using automated methods,
because it is irregularly shaped and shrinks
in aging and disease.
Researchers at New York University overcame this
problem by developing a novel, automated method of  
precisely sampling the hippocampus.  They validated this
approach and extended it to other brain regions.  By
combining hippocampal measures with other regional
measures, they were able to predict decline to Alzheimer's
Disease in Normal patients 7 years before clinical
symptoms were measurable (Mosconi et al, 2008), and
greatly increase diagnostic accuracy between Normal
(NL), Mild Cognitive Impairment (MCI), Alzheimer's
Disease (AD), and other dementias (FTD, LBD) .
Copyright 2006-2010 Abiant, Inc.
Abiant, Inc.  480 West Center Street, Suite 202, Grayslake, Illinois  60030
Multicenter trial, 538 patients  
Mosconi et al, 2008
Abiant has exclusively licensed the Automated Region of Interest technology developed at New York
University, and successfully has applied it to more than 700 glucose metabolism and amyloid PET scans
from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.  Precise, automated hippocampal
measurement is a key aspect of our diagnostic test in development.
Diagnosis
Sensitivity
Specificity
Accuracy
AD vs. NL
98%
98%
98%
AD vs. FTD
98%
94%
97%
AD vs. LBD
98%
100%
99%
MCI vs. NL
98%
92%
95%
Diagnosis...